Journal article
Mapping subcortical brain maturation during adolescence: Evidence of hemisphere- and sex-specific longitudinal changes
M Dennison, S Whittle, M Yücel, N Vijayakumar, A Kline, J Simmons, NB Allen
Developmental Science | Published : 2013
DOI: 10.1111/desc.12057
Abstract
Early to mid-adolescence is an important developmental period for subcortical brain maturation, but longitudinal studies of these neurodevelopmental changes are lacking. The present study acquired repeated magnetic resonance images from 60 adolescent subjects (28 female) at ages 12.5 and 16.5 years to map changes in subcortical structure volumes. Automated segmentation techniques optimized for longitudinal measurement were used to delineate volumes of the caudate, putamen, nucleus accumbens, pallidum, hippocampus, thalamus and the whole brain. Amygdala volumes were described using manual tracing methods. The results revealed heterogeneous maturation across the regions of interest (ROIs), and..
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